What Does Data in Use Mean?

Data in use refers to data that is not simply being passively stored in a stable destination, such as a central data warehouse, but is working its way through other parts of an IT architecture.

Techopedia Explains Data in Use

Although professionals sometimes recommend techniques like end-to-end encryption (E2EE) to protect data in use, others have questioned whether total data-in-use security is ever really possible. This questions has become more important as an increasing number of companies embrace the use of software as a service (SaaS) and other third-party services that process data in the cloud.